Omeprazole

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Omeprazole Description: IndicationsOmeprazole capsules are indicated for the treatment of:1.reflux oesophagitis 2.duodenal ulcer 3.gastric ulcer 4.NSAID-associated gastric and duodenal ulcers or erosions 5.Acid related dyspepsia 6.Zollinger-Ellison syndrome. In the treatment of peptic ulceration, the eradication of H.pylori, as the causative organism, must be a high priority.Accordingly, omeprazole capsules should be used as part of combination therapy for the eradication of H.pylori.Maintenance:Omeprazole capsules are indicated for maintenance treatment of:1.reflux oesophagitis 2.duodenal ulcer 3.gastric ulcer 4.Zollinger-Ellison syndrome. Dosage and Administration:Omeprazole capsules are recommended to be given in the morning and swallowed whole with half a glass of water. The contents of the capsule should not be chewed or crushed.Reflux oesophagitis:The recommended dosage is omeprazole capsules 20 mg once daily. In patients with severe reflux oesophagitis 40 mg once daily is recommended and healing is usually achieved within 8 weeks.For the long-term management of patients with healed reflux oesophagitis the recommended dose is 10 mg once daily. If needed the dose can be increased to 20-40 mg once daily.The recommended dosage regime for healing is: Weight Dosage 10-20 kg 10 mg daily > 20 kg 20 mg daily If needed dosage may be increased to 20 mg and 40 mg respectively.Helicobacter pylori (Hp) eradication regimens in peptic ulcer diseaseTriple therapy regimensOmeprazole capsules 20 mg, amoxicillin 1 g and clarithromycin 500 mg, all twice a day for one weekorOmeprazole capsules 20 mg, clarithromycin 250 mg and metronidazole 400 mg (or tinidazole 500 mg), all twice a day for one weekorOmeprazole capsules 40 mg once daily with amoxicillin 500 mg and metronidazole 400 mg both three times a day for one week.Dual therapy regimensOmeprazole capsules 40-80 mg daily with amoxicillin 1.5 g daily in divided doses for two weeks. In clinical studies daily doses of 1.5-3 g of amoxicillin have been usedorOmeprazole capsules 40 mg once daily and clarithromycin 500 mg three times a day for two weeks.To ensure healing in patients with active peptic ulcer disease, see further dosage recommendations for duodenal and gastric ulcer.In each regimen if the patient is still Hp positive, therapy may be repeated.Duodenal ulcerThe recommended dosage in patients with an active duodenal ulcer is omeprazole capsules 20 mg once daily. In patients with poorly responsive duodenal ulcer 40 mg once daily is recommended and healing is usually achieved within 4 weeks.For the prevention of relapse in patients with duodenal ulcer disease the recommended dose is 10 mg once daily. If needed the dose can be increased to 20-40 mg once daily.For NSAID-associated duodenal ulcers see "NSAID-Associated Gastroduodenal Lesions".Gastric ulcerThe recommended dosage is omeprazole capsules 20 mg once daily. In patients with poorly responsive gastric ulcer 40 mg once daily is recommended and healing is usually achieved within 8 weeks.For the prevention of relapse in patients with poorly responsive gastric ulcer the recommended dose is 20 mg once daily. If needed the dose can be increased to 40 mg once daily.For NSAID-associated gastric ulcers see "NSAID-Associated Gastroduodenal Lesions".NSAID-associated gastroduodenal lesionsFor NSAID-associated gastric ulcers, duodenal ulcers or gastroduodenal erosions in patients with or without continued NSAID treatment, the recommended dosage of omeprazole capsules is 20 mg once daily. For the prevention of NSAID-associated gastric ulcers, duodenal ulcers, gastroduodenal erosions and dyspeptic symptoms the recommended dosage is 20 mg once daily.Symptoms of Acid-related dyspepsiaFor the 24-hour relief, and prevention of symptoms in patients with epigastric pain/discomfort with or without heartburn and indigestion, 20 mg once daily in the morning for 14 -28 days*. If symptom control has not been achieved after 4 weeks treatment with 20 mg daily, further investigation is recommended.*Patients may respond adequately to 10 mg daily and this dose could be considered as a starting dose.Zollinger-Ellison syndromeIn patients with Zollinger-Ellison syndrome the dosage should be individually adjusted and treatment continued as long as is clinically indicated. The recommended initial dosage is omeprazole capsules 60 mg daily. All patients with severe disease and inadequate response to other therapies have been effectively controlled and more than 90% of the patients maintained on doses of 20-120 mg daily. When doses exceed 80 mg daily, the dose should be divided and given twice daily.

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Omeprazole Information:

Category: Prescription Drugs

Generic Drug Names: Generic Prilosec, Losec

Additional Information about Omeprazole: Affordable HealthCare

Omeprazole Pack Size Information:

Omeprazole

10mg

84(3 x 28) Tablets

10mg

28 Tablets

20mg

28 Tablets

20mg

84(3 x 28) Tablets

40mg

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